How LSD is Made: Everything You Need to Know
Jan 05, · Cool the ergotamine solution to near freezing in your freezer (to avoid desosphyxiation with CO2 in the air). Now, simply grind the pills into a powder and mix into your ergotamine solution. You now have lysergic acid. 4. You *want* LSD, lysergic acid diethylamide, however, and so you need to ethylate your compound and then ammonate it. Aug 06, · How to Make LSD: Key Procedures Explained. Step 1: Convert Ergot Amides to iso-Lysergic Acid Hydrazide. The semisynthesis of LSD begins with an ergot alkaloid like ergotamine. Ergine can be Step 2: Convert to Lysergic Acid Azide. Step 3: Form iso-Lysergic Acid Diethylamide. Step 4: Purify and.
LSD is, without a doubt, the king of hallucinogens. It is rather difficult to make by total synthesis, but with the right starting materials lysergic acid, ergotamine it is as easy to produce as your average THC or amphetamine. I call it the king because of the awesome potency, the usual hallucinogenic dose being about to micrograms orally.
This gives one gram of LSD the potential to contain 4, to 10, doses. As with the rest of this book, I will deal only with the synthetic manufacture of drugs LSD included. If you want to grow the ergot alkaloids that begin the total synthesis of LSD, then you will have to go to the Merck Index and look up the references to the operation.
Michael V. Smith's book, Psychedelic Chemistry, has a section on growing Claviceps purpurea, which yield ergot compounds. This section is very complete and informative, but I think that you should also look up the dangers of growing this fungus before doing it, as it causes a type of gangrene that can kill you not to mention making your arms and legs fall off upon contamination of your body.
As Mr. Smith's book states, this fungus is very temperamental, hard to obtain, even harder to grow and diffficult to work with. Smith's book gives many references and many formulas that you will not see here, but which are of what does getting high do to your body interest in the making of all hallucinogens not just LSD.
This does not make my book incomplete. On the contrary, I have given more than enough information to make every major type of drug. My book is not intended to cut in on Smith's book sales. It is intended to give you information and formulas that Smith's book lacks. Where he gives many different types of formulas, I give only the fast, simple and high yielding formulas. Also, you will not see the same formula in both his and my book, unless it is a general method and not specific.
What his book lacks, my book gives equipment, methods, basic chemistry, a wider variety of types of different classes of drugs, glossary terms, easier to understand wordage, how to buy and make precursors, etc. What my book lacks, his book gives more variety of hallucinogenic formulas, cultivation of pot and ergot, tests for activity, etc. I feel it would be a good idea to buy his book and try some of these harder formulas after learning the basics and practicing some of the formulas from my book, for complete understanding first.
Forgive me for wandering from the subject of LSD synthesis. As this first chapter of formulas is for psychedelics, I felt it necessary to explain the difference of the only other book of this type. If you are sharp, and have carefully read my chapter on buying precursors, you should be able to get lysergic acid from a supplier. Be warned, that the DEA must be informed of the purchase by the supplier, according to laws how do you convert cd files to mp3 them to do so.
Lysergic acid can be made. Following is the general method to give you a very good idea of the procedure and chemicals involved. By reacting N-benzoyl B-carboxyethyl -dihydroindole see JCS, for the preparation of this compound with thionyl chloride, followed by aluminum chloride gives 1-benzoylketo-1,2,2a,3,4,5-hexahydrobenzindole.
This is then brominated to give the 4-bromo-derivative, which is converted to the ketol-ketone by reacting with methylamine acetone ethylene ketol. This is then hydrolized by acid to yield the diketone and treated with sodium methoxide to convert it to the tetracyclic ketone. Acetylate and reduce this ketone with sodium borohydride to get the alcohol, which is converted to the hydrochloride form, as usual.
The above hydrochloride is treated with thionyl chloride in liquid sulfur dioxide, to produce an what causes rust on fuchsias chloride hydro chloride, which is converted to the nitrile with sodium cyanide in liquid hydrogen cyanide. Methanolysis then gives the ester of the nitrile.
Alkaline hydrolysis of this last compound, followed by catalytic dehydrogenation in water using a deactivated Raney Nickle catalyst see JOC. This is the easiest way to totally synthesize lysergic acid. There are other ways, but after reviewing other methods, I found this to be superior. It is quite complicated and it takes good modern equipment.
JACS, 78, The solution is mixed with g of Raney Nickle catalyst and hydrogenated at room temp in a steel bomb at about 3, psi until the uptake of hydrogen stops about hours. Filter off the catalyst and wash it with a little water to remove the product that is clinging to it.
Add 85 ml of concd HCl acid to the filtrate, and cool. If your reduction is incomplete, you will now have unreacted starting material separate, and this must be removed by filtration. Benzoylate the filtrate the Schotten and Baumann method is preferableusing ml of 12 N NaOH ml of benzoyl chloride. When the benzoyl chloride is fully reacted, the reaction mixture is cooled and acidified with ml of HCl acid.
Filter the crude product by filtration, wash with water, and extract with four 1 liter portions of hot water. Separate, and crystallize the resulting syrupy product from a few volumes of methanol. This is l-Benzoylbeta-carboxyethyl-2,3-dihydroindole. This can be purchased to eliminate this step.
This solution is allowed to stand for 30 min, then it is warmed gently for min on a steam bath. The crude acid chloride is dissolved in dry carbon disulfate. This solution is added, in a thin stream, to a well stirred suspension of g of aluminum chloride in ml of carbon disulfate in a 5, cc flask. Note: this must be done under a fume hood. A complex will separate and bog down the stirring device.
Heat this mixture under reflux with stirring for 1 hour. Decompose this mixture by adding g of ice, ml of concd HCl acid, and ml of water, all while good stirring is continued. Cooling of this operation is affected by periodic distillation of the carbon disulfate in vacuo. After the decomposition is complete, any remaining carbon disulfate is removed completely in vacuo, and the product is extracted with 2 liters of benzene.
The extract is washed well with ml of 2 N NaOH in three portions, and then with water. Dry with the usual magnesium sulfateand evaporate to a small volume in vacuo.
While the reaction is illuminated with a watt bulb, g of pyridine hydrobromide perbromide is added in portions, over 5 min with shaking. Treat the mixture with carbon, and evaporate to a small volume in vacuo. The residue is taken up with 2, ml of chloroform, and wash this solution with several portions of water, dry as above, and concentrate in vacuo.
Another crop can be obtained from concentrating the fltrates. Yield: 30 g of less what does a teardrop mean product. A solution of the last indole product above g and g of methylaminoacetone ethylene ketol in 4, ml of dry benzene is refluxed for 21 hours under a slow stream of nitrogen.
The mixture is cooled and g of methylaminoacetone ethylene ketol hydrobromide is filtered how to say you care about someone. The filtrate is washed with ice water, then extracted with 2. The acid extracts are immediately added to an excess of ice cold dilute NaOH.
Extract with 1 1iter of chloroform, dry over magnesium sulfate, treat with carbon and concentrate by evaporation in vacuo. Cool the mixture, treat with carbon, filter, and concentrate the filtrate in vacuo to a small volume. Treat the residue with an excess of sodium bicarbonate, extract with cold chloroform, and remove the chloroform by evaporation in vacuo at room temp. The crude diketone is powdered, how to get lysergic acid with 75 ml of benzene-ether, and filtered.
Yield: 9. Without exposure to air the crude ketone is immediately slurried with a little ice water can you check whatsapp messages online filtered. A second crop is obtained by concentrating the mother liquor by evaporation. A mixture of the last product 1. The catalyst is filtered and extracted with hot methanol and chloroform. The combined extract filtrates and the initial filtrate are combined and evaporated in vacuo.
The residue is recrystallized from water to give 0. This product is called 4-acetyl-4,5,5a,6-tetrahydrohydroxymethylindolo- 4,3fg -quinolinium hydroxide betaine. The solvent is distilled off, and the residue is taken up in a mixture of chloroform and water. The chloroform solution is separated, dried as above, and then the solvent is distilled off. The residue is recrystallized from a nitromethane-ethyl acetate mixture to yield 0.
Not only is this a small scale, but it is a poor yield, requiring you to perform it several times to get enough product to perform the next step. When you have more than enough, convert the product into its hydrochloride form by dissolving in dry methanol and precipitating with dry hydrogen chloride. Thionyl chloride 1. Vent the vessel carefully and remove the mixture. Evaporate the sulfur dioxide while keeping the volume of the solution constant by the slow addition of dry ether.
The amorphous chloro hydrochloride is filtered, washed with ether dry and dried by evaporating in vacuo to give 3. Speed up the stirring, continue the cooling, and add 7. The residue is mixed with chloroform and ice water, and the resulting mixture is filtered.
The organic layer of the filtrate is separated and the aqueous layer is extracted with two separate portions of chloroform.
The combined extracts this would include the separated chloroform, as usual are dried over magnesium sulfate, decolorized, and the solvent removed by distillation in vacuo. Crystallize the product in ethyl acetate. Yield: 3. Recrystallize again for extra purity. With external ice bath cooling how long does rid take to kill lice 2 ml of concd sulfuric acid slowly. Note: I have seen a big pressure cooker like gramma cans peas with work for some of these bomb procedures.
I do not recommend it, but here is how to do it right, if you feel you must.
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You can buy LSD (Lysergic Acid Diethylamide) blotter paper online cheap (in low price) LSD Blotter is one of the most potent, mood-changing chemicals. It is manufactured from lysergic acid, which is found in the ergot fungus that grows on rye and other grains. What is LSD? Buy LSD Online. It is produced in crystal form in illegal laboratories, mainly in the United States. Add g of ergotamine hydrochloride to 4 ml of anhydrous hydrazine and heat 1 hour at 90°. Add 20 ml of water and evaporate in vacuo, to get d-iso-lysergic acid hydrazine. 1 g of the lysergic hydrazine is powdered well and added to 40 ml of N (ice cold) HC1 acid. To this, cooled to 0°, is added 4 ml of 1 N Na nitrite, with good stirring.
LSD Blotter is one of the most potent, mood-changing chemicals. It is manufactured from lysergic acid, which is found in the ergot fungus that grows on rye and other grains.
It is produced in crystal form in illegal laboratories, mainly in the United States. These crystals are converted to a liquid for distribution. It is odorless, colorless, and has a slightly bitter taste.
Occasionally it is sold in liquid form. But no matter what form it comes in, LSD leads the user to the same place—a serious disconnection from reality. LSD Blotter , Lysergic acid diethylamide, also known as acid, is a psychedelic drug known for its psychological effects.
Lysergic acid diethylamide, also known as acid, is a psychedelic drug known for its psychological effects. Save my name, email, and website in this browser for the next time I comment. Buy Liquid Ketamine Online. Surgical Face Mask. Akorn Red 16 Oz 32 Oz. Remember me Log in. Lost your password? Add to Wishlist. What is LSD? Reviews There are no reviews yet.
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